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|
 Biotin-dPEG4-Hydrazide
| Product Name: |
Biotin-dPEG4TM-Hydrazide |
| QBD Product Number: |
10219 |
| Category |
Biotinylation Reagents with
Water Soluble, Non-immunogenic
Discrete PEG (dPEGTM) Spacer |
Quantities and Pricing
| Quantity |
Price (USD) |
| 50mg |
$250.00 |
| 1000mg |
$1,100.00 |
| |
|
| Bulk |
Please call for pricing. |
Attributes
| Reactivity 1 |
carbonyl |
| Reactivity 2 |
carboxylic acid |
| Spacer length (A) |
20.6 |
| Molecular Weight |
505.63 |
| Special Notes |
Reacts with aldehydes and ketones to give stable hydrazones in a single step. Physical properties similar to NHS-dPEG4TM-biotin (Product No. 10200). Chain length from amide carbonyl to formed hydrazone N is 20.6A. Hydrophilic spacer arm eliminates or minimizes non-specific binding that causes aggregation and precipitation problems, which commonly occur when labeling antibodies and other biological materials. Hydrophilic dPEGTM spacer is non-immunogenic. |
Protocols
| Greg T. Hermanson, Bioconjugate Techniques, Academic Press, Inc., San Diego, CA, 1996 (ISBN 0-12-342335-X). Greg gives the protocol for the coupling of the hydrazide to an oxidized glycoprotein. Note too that this can be carried out without the reduction with NaCNBH3 as well. However, the reduced forms are stable to a wider pH range. |
References
| Greg T. Hermanson, Bioconjugate Techniques, Academic Press, Inc., San Diego, CA, 1996 (ISBN 0-12-342335-X). Greg discusses applications for the biotin hydrazide, biotin-LC-hydrazide and biocytin hydrazide on pages 390-393. These are applicable to our reagent, with the additional vital benefits of having the hydrophilic spacer arm. |
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